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Mem 106 c18-cycad-induced neurodegeneration is different in rat & mouse models. sold by nybgshop.org for $4.99

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This purchase only includes chapter 18 of this title.

Abstract

In Guam and the western Pacific there are several neurodegenerative diseases linked to¬†the ingestion of the flour of the seeds of the cycad, Cycas micronesica. Grouped together,¬†these diseases are called Amyotrophic Lateral Sclerosis√Ę‚ā¨‚Äú Parkinsonism dementia complex¬†(ALS-PDC). PDC is currently one of the most prevalent diseases in the Chamorro¬†people of Guam and in New Guinea. There is also ALS, which has declined in prevalence¬†to rates that are comparable to those found elsewhere. In addition, there is a dementia,¬†whose incidence has been increasing. Some individuals have one of these neurodegenerative¬†diseases, and some have more than one. The original intent of the experiments¬†described below was to recreate the ALS form of ALS- PDC by feeding rats washed cycad¬†flour. Surprisingly, instead of developing ALS, as do CD1 mice upon cycad ingestion,¬†the rats developed parkinsonism. There was no loss of spinal motor neurons; however,¬†there was a loss of dopamine neurons in the substantia nigra pars compacta (SNc) and dopamine¬†terminals in the striatum. This finding also showed individual variability reminiscent¬†of the human disorder. Features of this disorder in rats include motor behavioral¬†deficits and biochemical abnormalities in neurons and glia including √é¬Ī-synuclein accumulation¬†in the SNc. The behavioral deficits are progressive, as is parkinsonism. In all¬†cases, these effects stem from the same source as that postulated to be the basis for PDC¬†in the Chamorro people: consumption of washed cycad flour as part of the diet. The¬†cycad flour we use does not contain the toxins traditionally associated with PDC¬†(BMAA [√é¬≤-methylamino-L-alanine] or cy




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